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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK9
All Species:
47.58
Human Site:
Y19
Identified Species:
69.78
UniProt:
P50750
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P50750
NP_001252.1
372
42778
Y19
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001094502
352
40482
R19
E
V
F
K
A
R
H
R
K
T
G
Q
K
V
A
Dog
Lupus familis
XP_548446
534
59045
Y181
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Cat
Felis silvestris
Mouse
Mus musculus
NP_570930
372
42743
Y19
F
C
D
E
V
T
K
Y
E
K
L
A
K
I
G
Rat
Rattus norvegicus
Q641Z4
372
42743
Y19
F
C
D
E
V
T
K
Y
E
K
L
A
K
I
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520593
314
36161
Chicken
Gallus gallus
Q5ZKN1
372
42784
Y19
F
C
D
E
V
S
K
Y
E
K
L
A
K
I
G
Frog
Xenopus laevis
Q4V862
376
43205
Y19
Y
C
D
E
V
S
K
Y
E
R
L
A
K
I
G
Zebra Danio
Brachydanio rerio
NP_997756
393
45129
Y40
F
C
D
E
F
S
K
Y
E
K
L
A
K
I
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477226
404
46768
Y50
Y
C
D
E
S
N
K
Y
E
K
V
A
K
I
G
Honey Bee
Apis mellifera
XP_396015
382
43973
Y24
H
C
D
E
S
S
K
Y
E
K
V
A
K
I
G
Nematode Worm
Caenorhab. elegans
Q9TVL3
478
53575
Y85
F
I
R
D
V
S
T
Y
E
K
L
N
K
I
G
Sea Urchin
Strong. purpuratus
XP_798269
410
46418
Y48
Y
C
E
E
V
S
K
Y
D
K
L
A
K
I
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LFT8
505
56711
F26
G
S
R
S
V
D
C
F
E
K
L
E
Q
I
G
Baker's Yeast
Sacchar. cerevisiae
P23293
657
74221
Y60
C
T
V
F
Q
N
H
Y
R
E
D
E
K
L
G
Red Bread Mold
Neurospora crassa
Q871M9
545
61347
Y26
G
C
S
R
I
A
D
Y
E
V
L
G
K
L
G
Conservation
Percent
Protein Identity:
100
N.A.
92.4
68.5
N.A.
98.6
98.6
N.A.
77.9
93
89.3
85.5
N.A.
66
72.7
43.3
67.3
Protein Similarity:
100
N.A.
93.5
69.4
N.A.
99.7
99.7
N.A.
80.3
95.4
94.1
89.5
N.A.
75.9
83.2
56.4
75.8
P-Site Identity:
100
N.A.
6.6
100
N.A.
93.3
93.3
N.A.
0
100
86.6
93.3
N.A.
73.3
80
66.6
80
P-Site Similarity:
100
N.A.
26.6
100
N.A.
100
100
N.A.
0
100
100
93.3
N.A.
93.3
86.6
73.3
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
36
25.2
31.7
Protein Similarity:
N.A.
N.A.
N.A.
51
39.4
45.6
P-Site Identity:
N.A.
N.A.
N.A.
40
20
40
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
40
60
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
7
7
0
0
0
0
0
63
0
0
7
% A
% Cys:
7
69
0
0
0
0
7
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
57
7
0
7
7
0
7
0
7
0
0
0
0
% D
% Glu:
7
0
7
63
0
0
0
0
75
7
0
13
0
0
0
% E
% Phe:
44
0
7
7
7
0
0
7
0
0
0
0
0
0
0
% F
% Gly:
13
0
0
0
0
0
0
0
0
0
7
7
0
0
88
% G
% His:
7
0
0
0
0
0
13
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
0
0
7
0
0
0
0
0
0
0
0
75
0
% I
% Lys:
0
0
0
7
0
0
63
0
7
69
0
0
88
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
69
0
0
13
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
13
0
0
0
0
0
7
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
7
0
0
0
0
0
0
7
7
0
0
% Q
% Arg:
0
0
13
7
0
7
0
7
7
7
0
0
0
0
0
% R
% Ser:
0
7
7
7
13
50
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
7
0
0
0
13
7
0
0
7
0
0
0
0
0
% T
% Val:
0
7
7
0
57
0
0
0
0
7
13
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
19
0
0
0
0
0
0
82
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _